The ICMR JRF (now often under DHR-ICMR BRET) is a prestigious national exam for Junior Research Fellowship in biomedical/medical research, leading to PhD admissions in top institutes. The exam has 125 questions to attempt: Section A (Aptitude/General Science/Stats – 50 compulsory, 1 mark each) + Section B (Life Sciences – attempt 75 out of 100, 1 mark each). Total 125 marks, 2-3 hours, -0.25 for wrong answers. Questions emphasize conceptual understanding in modern biology. With competition rising, focus on accuracy, high-weightage topics, and consistent mocks. This guide is tailored for Life Sciences aspirants targeting 2026 success.
1. Subject-wise Preparation Plan
ICMR JRF Life Sciences overlaps heavily with CSIR NET syllabus but leans toward biomedical applications (immunology, microbiology, human physiology, molecular biology). Divide prep into phases:
- Section A (Aptitude – 50 questions): Daily 1-1.5 hrs. Cover scientific phenomena, stats basics (mean, median, probability, hypothesis testing), logical reasoning, GK in sciences. Books: Quantitative Aptitude by RS Aggarwal, Analytical Reasoning by MK Pandey, basic stats from NCERT.
- Section B (Life Sciences – 75 attempted): Core subjects: Biochemistry, Molecular Biology, Cell Biology, Genetics, Immunology, Microbiology, Human Physiology, Biotechnology, Pharmacology.
- Months 1-2: Build foundation – read standard textbooks, make concept notes.
- Months 3-4: Deep dive + short notes for facts/formulas (enzymes, pathways, diseases).
- Months 5-6: Intensive MCQ practice (150-200/day) + revision.
Daily Schedule (8-10 hrs): 3 hrs theory, 2-3 hrs MCQs, 1-2 hrs revision, 1 hr Section A. Prioritize weak areas weekly.
2. Important Topics in Life Sciences
From PYQ analysis (2020-2025), 60-70% questions come from these high-yield areas:
- Molecular Biology & Biochemistry: DNA/RNA structure, replication, transcription, translation, enzymes, metabolism pathways (glycolysis, TCA, ETC), biomolecules, protein folding.
- Cell Biology: Cell organelles, cell cycle (mitosis/meiosis), signaling pathways, apoptosis, cancer biology basics.
- Genetics: Mendelian & non-Mendelian inheritance, genetic disorders, population genetics, mutations, gene mapping.
- Immunology: Innate/adaptive immunity, antibodies, MHC, vaccines, hypersensitivity, autoimmune diseases, cytokines.
- Microbiology & Pathology: Bacteria/virus structure, pathogenesis, antibiotics resistance, virology (COVID, HIV), microbial techniques.
- Human Physiology: Nervous, cardiovascular, respiratory, endocrine, reproductive systems; homeostasis, hormones.
- Biotechnology & Techniques: PCR, cloning, CRISPR, ELISA, blotting, bioinformatics basics.
- Others (frequent): Pharmacology (drug mechanisms), ecology/evolution basics, biophysics (rare but high-scoring).
Tip: Focus on application-based questions (e.g., disease mechanisms, techniques in research). Revise deficiencies, symptoms, and key experiments.
3. Previous Year Paper Strategy
PYQs (2018-2025) are gold – download from icmr.nic.in archives, ifasonline, or easybiologyclass.
- Solve subject-wise first to spot patterns (e.g., immunology 12-15 Qs, molecular bio 10-12 Qs).
- Attempt full papers timed (2-3 hrs) after 3 months prep.
- Analyze errors: Conceptual vs silly – maintain "Mistake Diary" for weekly revision.
- Target: 80-90% accuracy in PYQs before mocks. Many toppers gain 20-30 marks from repeats/variations.
Practice 8-10 years' papers; note recurring themes like immune disorders, metabolic pathways.
4. Mock Test Strategy
Mocks build stamina, time management, and accuracy (negative marking is killer – attempt only 80-90% sure ones).
- Frequency: 1 mock/week initially → 2-3/week in last 3 months.
- Sources: Biotecnika, IFAS, Shomu's Biology mocks, Amazon ICMR JRF mock books, or platforms like Testbook/PW.
- Post-Mock: 2-3x time analyzing – weak topics, time traps (Section A quick, Life Sci deep).
- Approach: Attempt Section A first (fast scoring), then Life Sci in 2 rounds – sure → doubtful.
- Score Goals: Early: 70-85 → Mid: 95-110 → Final: 115+ consistently for top ranks.
Take 30-50 full mocks; simulate exam conditions (no breaks, quiet room).
5. 3–6 Month Study Plan
6-Month Plan (Ideal – Start Now):
- Month 1-2: Cover syllabus + Section A basics. Read Lehninger (Biochem), Alberts (Cell/Mol Bio), Kuby (Immunology).
- Month 3: Complete high-yield topics + start PYQs subject-wise.
- Month 4: Intensive revision + daily 150 MCQs. Make mind maps for pathways/diseases.
- Month 5: Full mocks + error correction. Revise notes 3x.
- Month 6: 3 mocks/week, quick revisions, focus on weak units. Stay calm!
3-Month Crash Plan (Intense): Prioritize high-weightage (Mol Bio, Immunology, Genetics, Physiology) + PYQs + 2 mocks/week. Cover Section A in 2 weeks. Revise daily.
Track progress weekly; stay healthy – 7 hrs sleep, exercise. Check icmr.nic.in for 2026 notification (likely May-June application, July exam).
ICMR JRF rewards conceptual depth + smart practice over rote learning. Consistency, PYQ focus, and mock analysis are key to 110+ scores and fellowship. You've got this – stay dedicated and aim high for that ICMR JRF success! 🧬🔬